Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms

Soheil Mohammadi, Fatemeh Moosaie, Mohammad Hadi Aarabi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Similar to its predecessors, coronavirus disease 2019 (COVID-19) exhibits neurotrophic properties, which lead to progression of neurologic sequelae. Besides direct viral invasion to the central nervous system (CNS), indirect CNS involvement through viral-mediated immune response is plausible. Aberrant immune pathways such as extreme release of cytokines (cytokine storm), autoimmunity mediated by cross-reactivity between CNS components and viral particles, and microglial activation propagate CNS damage in these patients. Here, we review the currently available evidence to discuss the plausible immunologic pathways that may contribute to the development of COVID-19 neurological complications, namely Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, Guillain-Barre syndrome, seizure, and brainstem involvement.
Original languageEnglish
JournalMolecular Neurobiology
Volume57
Issue number12
DOIs
StatePublished - 1 Dec 2020

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