Halting coronavirus polymerase

Research output: Contribution to journalArticle


© 2020 Kirchdoerfer. The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNAdependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.
Original languageEnglish
JournalJournal of Biological Chemistry
Issue number15
StatePublished - 10 Apr 2020

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