Applying phylogenetic analysis to viral livestock diseases: Moving beyond molecular typing

Alex Olvera, Núria Busquets, Marti Cortey, Nilsa de Deus, Llilianne Ganges, José Ignacio Núñez, Bibiana Peralta, Jennifer Toskano, Roser Dolz

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Changes in livestock production systems in recent years have altered the presentation of many diseases resulting in the need for more sophisticated control measures. At the same time, new molecular assays have been developed to support the diagnosis of animal viral disease. Nucleotide sequences generated by these diagnostic techniques can be used in phylogenetic analysis to infer phenotypes by sequence homology and to perform molecular epidemiology studies. In this review, some key elements of phylogenetic analysis are highlighted, such as the selection of the appropriate neutral phylogenetic marker, the proper phylogenetic method and different techniques to test the reliability of the resulting tree. Examples are given of current and future applications of phylogenetic reconstructions in viral livestock diseases. © 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
JournalVeterinary Journal
Volume184
Issue number2
DOIs
StatePublished - 1 May 2010

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