A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2

Yo Min Liu, Md Shahed-Al-Mahmud, Xiaorui Chen, Ting Hua Chen, Kuo Shiang Liao, Jennifer M. Lo, Yi Min Wu, Meng Chiao Ho, Chung Yi Wu, Chi Huey Wong, Jia Tsrong Jan, Che Ma

Research output: Contribution to journalArticlepeer-review

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Abstract

© 2020 The Authors Liu et al. demonstrate that FRIL, a plant lectin isolated from the hyacinth bean, has potent antiviral activity against SARS-CoV-2 and diverse influenza virus strains. FRIL is effective in vivo against H1N1. FRIL's antiviral activity is mediated by binding to complex-type N-glycans on viral glycoproteins, interfering with viral entry.
Original languageEnglish
JournalCell Reports
Volume32
Issue number6
DOIs
StatePublished - 11 Aug 2020

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