© American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: firstname.lastname@example.org. The recent SARS-CoV-2 outbreak has placed immense pressure on supply chains, including shortages in nasopharyngeal (NP) swabs. Here, we report our experience of using 3D-printing to rapidly develop and deploy custom-made NP swabs to address supply shortages at our healthcare institution.