20182020

Research output per year

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Fingerprint Dive into the research topics where Maria L. Agostini is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Relevant Research

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

Sheahan, T. P., Sims, A. C., Zhou, S., Graham, R. L., Pruijssers, A. J., Agostini, M. L., Leist, S. R., Schäfer, A., Dinnon, K. H., Stevens, L. J., Chappell, J. D., Lu, X., Hughes, T. M., George, A. S., Hill, C. S., Montgomery, S. A., Brown, A. J., Bluemling, G. R., Natchus, M. G., Saindane, M. & 8 others, Kolykhalov, A. A., Painter, G., Harcourt, J., Tamin, A., Thornburg, N. J., Swanstrom, R., Denison, M. R. & Baric, R. S., 29 Apr 2020, In : Science Translational Medicine. 12, 541

Research output: Contribution to journalArticle

Open Access
  • 16 Scopus citations

    Fitness barriers limit reversion of a proofreading-deficient coronavirus

    Graepel, K. W., Agostini, M. L., Lu, X., Sexton, N. R. & Denisona, M. R., 1 Oct 2019, In : Journal of Virology. 93, 20

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Small-molecule antiviral β-d-n4-hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance

    Agostini, M. L., Pruijssers, A. J., Chappell, J. D., Gribble, J., Lu, X., Andres, E. L., Bluemling, G. R., Lockwood, M. A., Sheahan, T. P., Sims, A. C., Natchus, M. G., Saindane, M., Kolykhalov, A. A., Painter, G. R., Baric, R. S. & Denison, M. R., 1 Dec 2019, In : Journal of Virology. 93, 24

    Research output: Contribution to journalArticle

    Open Access
  • 11 Scopus citations

    Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease

    Agostini, M. L., Andres, E. L., Sims, A. C., Graham, R. L., Sheahan, T. P., Lu, X., Smith, E. C., Case, J. B., Feng, J. Y., Jordan, R., Ray, A. S., Cihlar, T., Siegel, D., Mackman, R. L., Clarke, M. O., Baric, R. S. & Denison, M. R., 1 Mar 2018, In : mBio. 9, 2

    Research output: Contribution to journalArticle

    Open Access
  • 152 Scopus citations