Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version)

  • Ying Hui Jin (Contributor)
  • Qing Yuan Zhan (Contributor)
  • Zhiyong Peng (Contributor)
  • Xue Qun Ren (Contributor)
  • Xun Tao Yin (Contributor)
  • Lin Cai (Contributor)
  • Yu Feng Yuan (Contributor)
  • Ji Rong Yue (Contributor)
  • Xiao Ju Zhang (Contributor)
  • Qi Wen Yang (Contributor)
  • Jianguang Ji (Contributor)
  • Jian Xia (Contributor)
  • Hong Jun Li (Contributor)
  • Fu Xiang Zhou (Contributor)
  • Yadong Gao (Contributor)
  • Zhui Yu (Contributor)
  • Feng Xu (Contributor)
  • Ming Li Tu (Contributor)
  • Li Ming Tan (Contributor)
  • Qi Wen Yang (Contributor)
  • Wen Chen (Contributor)
  • Xiao Ju Zhang (Contributor)
  • X. Zeng (Contributor)
  • Zhui Yu (Contributor)
  • Xin Can Liu (Contributor)
  • Qi Wen Yang (Contributor)
  • Ming Juan Zhao (Contributor)
  • Yu Feng Ding (Contributor)
  • Ning Hou (Contributor)
  • Xue Jun Wang (Contributor)
  • Wen Chen (Contributor)
  • Xiao Ju Zhang (Contributor)
  • Hong Jun Li (Contributor)
  • Wen Chen (Contributor)
  • Yue Xian Shi (Contributor)
  • Qi Wen Yang (Contributor)
  • Xue Jun Wang (Contributor)
  • Yanjun Zhong (Contributor)
  • Ming Juan Zhao (Contributor)
  • Hong Jun Li (Contributor)
  • Lin Lu Ma (Contributor)
  • Hao Zi (Contributor)
  • Xue Jun Wang (Contributor)
  • Xue Jun Wang (Contributor)
  • Zhui Yu (Contributor)
  • Hong Jun Li (Contributor)
  • Di Huang (Contributor)
  • Hong Weng (Contributor)
  • Xue Qun Ren (Contributor)
  • Li Sha Luo (Contributor)
  • Man Ru Fan (Contributor)
  • Di Huang (Contributor)
  • Hong Yang Xue (Contributor)
  • Zhui Yu (Contributor)
  • Yadong Gao (Contributor)
  • Tong Deng (Contributor)
  • X. Zeng (Contributor)
  • Hong Jun Li (Contributor)
  • Zhen Shun Cheng (Contributor)
  • Xiao Mei Yao (Contributor)
  • Xue Jun Wang (Contributor)

Dataset

Description

Abstract The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued “A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)”; now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline. We formed a working group of clinical experts and methodologists. The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas: chemoprophylaxis, diagnosis, treatments, and discharge management. We searched the literature for direct evidence on the management of COVID-19, and assessed its certainty generated recommendations using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Recommendations were either strong or weak, or in the form of ungraded consensus-based statement. Finally, we issued 34 statements. Among them, 6 were strong recommendations for, 14 were weak recommendations for, 3 were weak recommendations against and 11 were ungraded consensus-based statement. They covered topics of chemoprophylaxis (including agents and Traditional Chinese Medicine (TCM) agents), diagnosis (including clinical manifestations, reverse transcription-polymerase chain reaction (RT-PCR), respiratory tract specimens, IgM and IgG antibody tests, chest computed tomography, chest x-ray, and CT features of asymptomatic infections), treatments (including lopinavir-ritonavir, umifenovir, favipiravir, interferon, remdesivir, combination of antiviral drugs, hydroxychloroquine/chloroquine, interleukin-6 inhibitors, interleukin-1 inhibitors, glucocorticoid, qingfei paidu decoction, lianhua qingwen granules/capsules, convalescent plasma, lung transplantation, invasive or noninvasive ventilation, and extracorporeal membrane oxygenation (ECMO)), and discharge management (including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge). We also created two figures of these recommendations for the implementation purpose. We hope these recommendations can help support healthcare workers caring for COVID-19 patients.
Date made available1 Jan 2020
PublisherFigshare - Springer

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